Recently, the term “renal maldevelopment” (RM) has been proposed to replace the old and sometimes misused term “renal dysplasia” in order to describe a type of juvenile-onset chronic kidney disease (JOCKD). Other congenital disorders described in the veterinary literature are juvenile or familial renal disease and hereditary nephropathy. Distinct histopathological features characterize renal dysplasia, such as the presence of metaplastic cartilages, primitive ducts and lobar disorganization without inflammation. Renal dysplasia is a frequently described congenital disease in veterinary medicine, defined as a disorganized development of the renal parenchyma due to an abnormal differentiation. Due to its possible inheritance, an early diagnosis of RM may allow clinicians to promptly identify other potentially affected dogs among the relatives of the diagnosed case. Renal maldevelopment should be suspected in young Boxer dogs with a history of PU/PD, decreased appetite, weight loss, lethargy, weakness and proteinuria. In 7 related dogs, the pedigree analysis showed that a simple autosomal recessive trait may be a possible mode of inheritance. Histopathology of the kidneys revealed the presence of immature glomeruli in all dogs, which is consistent with RM. Common laboratory findings were proteinuria, diluted urine, non-regenerative anemia, azotemia, hyperphosphatemia, hypoalbuminemia and hypercholesterolemia. Polyuria and polydipsia (PU/PD), decreased appetite, weight loss, lethargy and weakness were described in all affected dogs. Medical records of 9 female Boxer dogs, older than 5 months and with a clinical diagnosis of chronic kidney disease prior to one year of age, were retrospectively reviewed. This study reports clinical and renal histological findings in Boxer dogs with RM, proposing a possible mode of inheritance. Although renal dysplasia has been described in Boxers, hereditary transmission has only been hypothesized. Renal maldevelopment (RM) has been proposed to replace the old and sometimes misused term “renal dysplasia” in dogs. A routine clinical renal screening evaluation in this breed, especially when this disease is suspected, should be strongly recommended. A prompt diagnosis of renal maldevelopment, potentially hereditary, may help to evaluate if relatives of the affected dogs might be at risk, thus assisting clinicians in reaching an early diagnosis. Renal glomerular immaturity should be suspected in Boxer dogs with a history of polyuria, polydipsia, decreased appetite, weight loss, lethargy, weakness and proteinuria. In 7 out of 9 related dogs, the pedigree analysis showed that a simple autosomal recessive trait may be a possible mode of inheritance. Histopathology of the kidneys identified the presence of immature glomeruli in all dogs. Common laboratory findings were proteinuria and diluted urine, non-regenerative anemia, azotemia, hyperphosphatemia, hypoalbuminemia and hypercholesterolemia. Medical records of 9 female Boxer dogs, older than 5 months and with a clinical diagnosis of proteinuric chronic kidney disease prior to one year of age, showed the presence of polyuria and polydipsia, decreased appetite, weight loss, lethargy and weakness in all affected dogs. This study describes clinical findings in Boxer dogs with renal maldevelopment and proposes a possible mode of inheritance.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |